Development of a Clinical Research Agenda for Acute Kidney Injury Using an International, Interdisciplinary, Three-Step Modified Delphi Process

Kellum et al. (2008) full text summary PDF

For which topic were research priorities identified?

acute kidney injury

In which location was the research priority setting conducted?


Why was it conducted at all?

Although acute kidney injury is common and significantly increases the risk for intensive care unit and hospital mortality, little is known about its true incidence or how it can be prevented. Furthermore, key unanswered questions remain about the optimal diagnosis and treatment of patients with acute kidney injury

What was the objective?

to guide clinical and translational research in acute kidney injury

What was the outcome?

a ranking list of 20 research questions

How long did the research prioritization take?

3 days

Which methods were used to identify research priorities?


How were the priorities for research identified exactly?

Step 1: Delphi round 1: via focus groups, participants discussed possible research questions, in addition literature review to identify key unanswered questions. Step 2: Delphi round 2: via meeting: questions from each of the six focus groups presented to entire committee, feedback provided, questions refined. Step 3: Delphi round 3: survey asking participants to rate each question

Which stakeholders took part?

Professional societies, guideline development organizations and policy and funding agencies, practitioners (nephrology, critical care medicine, pediatrics), researchers. 40 participants in all 3 Delphi rounds.

How were stakeholders recruited?

The project team contacted each society individually and requested that they select delegates to send to a 3-d conference, held in Vancouver, British Columbia, Canada.

Were stakeholders actively involved or did they just participate?

Stakeholders were mere participants of the research prioritization process; they were not actively involved in the process.